cereneo is specialised in the therapy approach and the high intensity of the treatments. Thanks to the close relationship between the clinic and the world of science, cereneo is always at the forefront of research. The latest measurement processes and newest therapeutic possibilities are used here.
The worldwide network of specialists and the proximity and cooperation with universities not only motivate the team but also enable the patient to make the best possible progress.
Neurological illness / acute treatment
Damage to the central nervous system often results in a loss of different bodily functions (e.g. speaking, swallowing, cognitive and movement functions) with direct and indirect consequences for many areas of daily life. This damage can arise, amongst other things, as a result of strokes, multiple sclerosis, Parkinson's disease or craniocerebral injury.
The rehabilitation process starts with the precise analysis and characterisation of the symptoms and deficits. The complexity of the limitations requires an interdisciplinary approach to therapy, whereby the different professional groups work closely together. Intensive and targeted training based around daily life is necessary to support the recovery of brain functions and the ability to relearn tasks from everyday life. In order to identify the areas to be trained, the process starts with the doctor and therapist carefully recording the symptoms and performing an exact analysis of the deficits using technical measurement processes. This includes walking analysis with 3D movement measurements and power and muscle activity measurements or surrogate markers from magnetic resonance imaging, evoked potential or EEGs.
The overriding goal is to work together with patients to offer them the greatest degree of independence in their living situation and continually improve their quality of life. The goals of the therapy are defined taking into account the patient's moral views and the individual wishes of the patient and their relatives.
As part of the cereneo therapy concept a patient-specific therapy programme is developed at the start of each rehabilitation phase. The therapy combines various training methods, which all attempt to achieve maximum therapy intensity (duration); this is determined by the performance and motivation of the patient.
The following therapies are used:
- Manual movement therapy (physiotherapy/ergotherapy) is based on the concept of forced use, whereby exercises that progressively always demand maximum effort from the patient are used to modify movement patterns towards physiological movement
- Robot-supported movement training for the arm (Armeo Power, Armeo Spring, Hocoma AG, Volketswil, Switzerland; Amadeo, Tyromotion GmbH, Graz, Austria) and leg (Lokomat, Hokoma AG)
- Dynamic partial weight release (Zero G, Aretech LLC Ashburn, USA)
- Dynamic power and precision training for the legs (Allegro, Dynamic Devices AG, Zurich, Switzerland)
- Virtual reality and mirror training (YouRehab, Schlieren, Switzerland)
- SplitBelt treadmill training (Bertec Inc, Columbus, USA)
- Speech and speaking therapy
- Training of swallowing and tongue movement
- Neurocognitive training (exercises, computer programmes) in neuropsychology
Alongside these, we also use supporting rehabilitative procedures:
- Transcranial DC stimulation (tDCS)
- Repetitive transcranial magnetic stimulation (rTMS)
- Medicinal therapy approaches
FLEXIBILITY HAND IN HAND
Interdisciplinary cooperation is very important and, whenever required, specialist areas are combined for specific treatments to support the patient in the best way possible.
RESEARCH & TECHNOLOGY
Research forms the basis for personalised treatments at the highest level. Research and treatment go hand in hand at cereneo. Thanks to the close connection between the clinic and the world of science, cereneo is always at the forefront of knowledge and deploys the latest measuring processes and the newest therapeutic possibilities. Particularly in a relatively new research field such as neurorehabilitation the latest results must be critically evaluated before they can be integrated into a treatment.
cereneo performs basic and clinical research. As a research clinic cereneo uses complex technologies (structural and functional MRI, EEG, TMS) when researching brain recovery and developing new therapy approaches. The processes for measuring brain anatomy and function, for brain stimulation and movement analysis create instruments used for helping to answer important questions in the field of neurorehabilitation.
During the course of the treatment continual measurements and assessments illustrate the recovery progress.
Every day the patient is informed by their reference person about their training performance and improvements – a significant factor for motivation. Research and development at cereneo also play an important role here.
For example, a monitoring and feedback system is developed that - in a similar way to the activity trackers commonly used nowadays in the field of leisure - can record the patient's therapy and sometimes also leisure activities and provide daily summaries. During regular interdisciplinary conferences, neurologists, physiotherapists, occupational therapists, speech therapists, neuropsychologists, nutritionists and experts on rehabilitative care meet to define, review, document and potentially adjust the therapeutic approach. If adjustments are required, the symptoms are reassessed and corresponding therapy measures identified. The effectiveness of these measures is again reviewed through regular measurements and assessments.
"cereneo offers a unique connection between modern neurorehabilitation and the bases of neuro-scientific research. The imaging techniques used on our premises and the highly modern laboratory enable us to record precisely the patient's progress. The biggest motivator for me is experiencing this directly and performing the ongoing therapies tailored to the individual needs of the patient."
Dr. Kai Lutz, Scientific Director
Study on improving arm function after strokes through intensive training 2 – SMARTS 2
SMARTS 2 is a randomised, blind, multi-centric study that investigates the effect of intensive robot therapy on the arm after a stroke.
A stroke often leads to limitations in arm movement that does not fully return for many patients. Intensive training is important for complete regeneration. The robot therapy represents a promising opportunity for patients after a stroke. However, it is unclear whether the robot therapy is superior to standard neurorehabilitation.
Our research question here is as follows: can arm movement be improved by patients receiving robot therapy after a stroke rather than a standard therapy?
Interaction – observation of stroke patients in the clinic and at home
Interaction is an observational study, whereby the movements of stroke patients are observed using a sensor-based whole body suit at cereneo and then at home after their release.
The aim of the study is to review the quality and quantity of movements in daily life, in order to follow improvements or deteriorations in the use of arms and legs during the rehabilitation process.
Increased motivation and optimised intensity in stroke rehabilitation
During stroke rehabilitation it is important that the affected patients train intensively and actively during their stay in the rehabilitation clinic. When it comes to optimising the patient's training activities, clinics are normally restricted by limitations in personnel and the infrastructure. At cereneo different approaches for increasing the intensity of the therapy are implemented and verified on the basis of studies. The aim is to increase the patient's motivation through various interventions to raise the intensity of the training. Outside of the therapies performed, the patients also have various opportunities for self-training, so that they can use their stay in the clinic to the full. To be able to use the infrastructure and clinic personnel in the best way possible for training, a programme for mathematically optimising the training plan on the basis of the resources available is being developed.
During the course of the various studies at cereneo, the patient's activities and training successes are systematically recorded and documented in a form that can be evaluated. Value is placed on automating the documentation processes, incorporating them into daily life at the clinic and publishing them so that they can also be adopted by other clinics. The data generated forms an important building block for research into improving recovery after a stroke.
The ArmeoSenso Reward study is a randomised, multi-centric study with the aim of investigating the influence of motivation on the success of therapies undertaken by stroke patients. The sensor-based arm therapy system (ArmeoSenso) is used in two different versions. These versions differ in a few game-specific points but the basic characteristics of the game remain the same. All of the participants train for 15 hours spread across 3 weeks, in addition to a standard therapy. The movements produced by the patients and the scope of the therapy remain comparable between the study groups. Possible differences between the groups in terms of the success of the therapy could be assigned to the motivating aspects of the therapy game.
In order to quantify the success of the therapy, standard clinical assessments (e.g. Fugl-Meyer assessment and Wolf Motor Function Tests) are performed by blind assessors before, after and 3 months after the 3-week training intervention. Furthermore, the movement range of each patient in the study is recorded before and after each therapy session in an automated assessment.
fMRI Reward Assessment
In a dexterity test, performed in a magnetic resonance imaging system (MRI), small amounts of money can be won depending on the performance shown. This leads to the activation of specific reward areas in the brain, which can be measured using functional magnetic resonance imaging (fMRI). In a study with healthy test persons, we were able to show that these activations have a positive influence on the process of learning the dexterity test. These same processes could positively influence the progress of the therapy undertaken by stroke patients. However, the ability of these reward areas to be activated may be reduced in stroke patients.
In the study described here we want to therefore use this dexterity test as an assessment to identify factors (e.g. age, localisation of the stroke, degree of affected movements etc.) that could lead to reduced activations in stroke patients. Furthermore, we also want to use the assessment to clarify with healthy test persons whether the brain activation measured is age-dependent.
Separable systems for recovery of finger strength and control after stroke
Xu, J., Ejaz, N., Hertler, B., Branscheidt, M., Widmer, M., Faria, A. V., ... & Kitago, T. (2017). Separable systems for recovery of finger strength and control after stroke. Journal of neurophysiology, 118(2), 1151-1163
Thermodilution-determined Internal Jugular Venous Flow
Rasmussen, P., Widmer, M., Hilty, M. P., Hug, M., Sørensen, H., Ogoh, S., ... & Lundby, C. (2017). Thermodilution-determined Internal Jugular Venous Flow. Medicine and science in sports and exercise, 49(4), 661-668
Elderly adults show higher ventral striatal activation in response to motor performance related rewards than young adults
Widmer, M., Stulz, S., Luft, A. R., & Lutz, K. (2017). Elderly adults show higher ventral striatal activation in response to motor performance related rewards than young adults. Neuroscience letters, 661, 18-22
Does motivation matter in upper-limb rehabilitation after stroke? ArmeoSenso- Reward: study protocol for a randomized controlled trial
Widmer, M., Held, J. P., Wittmann, F., Lambercy, O., Lutz, K., & Luft, A. R. (2017). Does motivation matter in upper-limb rehabilitation after stroke? ArmeoSenso-Reward: study protocol for a randomized controlled trial. Trials, 18(1), 580
Metacognitive Confidence Increases with, but Does Not Determine, Visual Perceptual Learning
Zizlsperger L, Kümmel F, Haarmeier T (2016) Metacognitive Confidence Increases with, but Does Not Determine, Visual Perceptual Learning. PLoS ONE 11(3): e0151218. doi:10.1371/journal. pone.0151218
Risk of Malnutrition Is an Independent Predictor of Mortality, Length of Hospital Stay, and Hospitalization Costs in Stroke Patients
Bounoure L, Gomes F, Stanga Z, Keller U, Meier R, Ballmer P, Fehr R, Mueller B, Genton L, NormBounoure L, Gomes F, Stanga Z, Keller U, Meier R, Ballmer P, Fehr R, Mueller B, Genton L, Norman K, et al. (2016) Detection and treatment of medical inpatients with or at-risk of malnutrition: suggested procedures based on validated guidelines. Nutrition. 32(7-8):790-8
Detection and treatment of medical inpatients with or at-risk of malnutrition: Suggested procedures based on validated guidelines
Gomes F., Emery P. W., Weekes C.E. (2016) Risk of Malnutrition Is an Independent Predictor of Mortality, Length of Hospital Stay, and Hospitalization Costs in Stroke Patients. Journal of Stroke and Cerebrovascular Diseases. 25(4): 799-806
Processing of Motor Performance Related Reward After Stroke.
M. Widmer, A.R. Luft, K. Lutz (2016) In J. Ibáñez et al. (eds.), Converging Clinical and Engineering Research on Neurorehabilitation II, Biosystems & Biorobotics 15, DOI 10.1007/978-3-319-46669-9_165
Rewarding feedback promotes motor skill consolidation via striatal activity.
M.Widmer, N. Ziegler, J. Held, A. Luft, K. Lutz (2016) Progress in Brain Resarch, Volume 229, ISSN 0079-6123, http://dx.doi.org/10.1016/bs.pbr.2016.05.006
Self-directed arm therapy at home after stroke with sensor-based virtual reality training system.
Wittmann et al. Journal of NeuroEngineering and Rehabilitation (2016) 13:75. DOI 10.1186/s12984-016-0182-1
RCP ISWP evidence-based guidelines for the secondary prevention of stroke through nutritional or dietary modification.
Hookway C., Gomes F., Weekes C.E. (2015) Royal College of Physicians Intercollegiate Stroke Working Party evidence-based guidelines for the secondary prevention of stroke through nutritional or dietary modification. In: J HUM NUTR DIET. 28(2):107-125. doi: 10.1111/jhn.12248
Assessment-driven arm therapy at home using an IMU-based virtual reality system.
F. Wittmann et. al (2015) 978-1-4799-1808-9/15/$31.00
RCP ISWP evidence-based guidelines for the nutritional support of patients who have had a stroke
Gomes F., Hookway C., Weekes C.E. (2014) Royal College of Physicians Intercollegiate Stroke Working Party evidence-based guidelines for the nutritional support of patients who have had a stroke. In: J HUM NUTR DIET, 27(2):107-121. doi: 10.1111/jhn.12185
What can the monetary incentive delay task tell us about the neural processing of reward and punishment?
A full body sensing system for monitoring stroke patients in a home environment.
B.Klaassen et al. (2014)
Gutzeit, Andreas; Meier, Dieter; Froehlich, Johannes M.; Hergan, Klaus; Kos, Sebastian; Weymarn, Constantin v. et al. (2013): Differential NMR spectroscopy reactions of anterior/posterior and right/left insular subdivisions due to acute dental pain. In: EUROPEAN RADIOLOGY 23 (2), S. 450–460. DOI: 10.1007/s00330-012-2621-0.
Hosp, J. A.; Mann, S.; Wegenast-Braun, B. M.; Calhoun, M. E.; Luft, A. R. (2013): REGION AND TASK-SPECIFIC ACTIVATION OF ARC IN PRIMARY MOTOR CORTEX OF RATS FOLLOWING MOTOR SKILL LEARNING. In: NEUROSCIENCE 250, S. 557–564. DOI: 10.1016/j.neuroscience.2013.06.060.
Lam, Judith M.; Waechter, Tobias; Globas, Christoph; Karnath, Hans-Otto; Luft, Andreas R. (2013): Predictive value and reward in implicit classification learning. In: HUMAN BRAIN MAPPING 34 (1), S. 176–185. DOI: 10.1002/hbm.21431.
Sulzer, J.; Haller, S.; Scharnowski, F.; Weiskopf, N.; Birbaumer, N.; Blefari, M. L. et al. (2013): Real-time fMRI neurofeedback: Progress and challenges. In: NEUROIMAGE 76 (1), S. 386–399. DOI: 10.1016/j.neuroimage.2013.03.033
In: NEUROIMAGE. Neurofeedback-mediated self-regulation of the dopaminergic midbrain.
Sulzer, James; Sitaram, Ranganatha; Blefari, Maria Laura; Kollias, Spyros; Birbaumer, Niels; Stephan, Klaas Enno et al. (2013): Neurofeedback-mediated self-regulation of the dopaminergic midbrain. In: NEUROIMAGE 83, S. 817–825. DOI: 10.1016/j.neuroimage.2013.05.115
Vigaru, Bogdan C.; Lambercy, Olivier; Schubring-Giese, Maximilian; Hosp, Jonas A.; Schneider, Melanie; Osei-Atiemo, Clement et al. (2013): A Robotic Platform to Assess, Guide and Perturb Rat Forelimb Movements. In: IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING 21 (5), S. 796–805. DOI: 10.1109/TNSRE.2013.2240014
Bruegger, M.; Lutz, K.; Broennimann, B.; Meier, M. L.; Luechinger, R.; Barlow, A. et al. (2012): Tracing Toothache Intensity in the Brain. In: JOURNAL OF DENTAL RESEARCH 91 (2), S. 156–160. DOI: 10.1177/0022034511431253
Hubli, Michele; Bolliger, Marc; Limacher, Esther; Luft, Andreas R.; Dietz, Volker (2012): Spinal neuronal dysfunction after stroke. In: EXPERIMENTAL NEUROLOGY 234 (1), S. 153–160. DOI: 10.1016/j.expneurol.2011.12.025
In: JOURNAL OF CLINICAL PERIODONTOLOGY Brain activation induced by dentine hypersensitivity pain-an fMRI study.
Meier, Michael L.; Bruegger, Michael; Ettlin, Dominik A.; Luechinger, Roger; Barlow, Ashley; Jaencke, Lutz; Lutz, Kai (2012): Brain activation induced by dentine hypersensitivity pain-an fMRI study. In: JOURNAL OF CLINICAL PERIODONTOLOGY 39 (5), S. 441–447. DOI: 10.1111/j.1600-051X.2012.01863.x
In: STROKE Consequences of Stroke in Community-Dwelling Elderly The Health and Retirement Study, 1998 to 2008.
Divani, Afshin A.; Majidi, Shahram; Barrett, Anna M.; Noorbaloochi, Siamak; Luft, Andreas R. (2011): Consequences of Stroke in Community-Dwelling Elderly The Health and Retirement Study, 1998 to 2008. In: STROKE 42 (7), S. 1821–1825. DOI: 10.1161/STROKEAHA.110.607630
Globas, Christoph; Lam, Judith M.; Zhang, Weihong; Imanbayev, Anuar; Hertler, Benjamin; Becker, Clemens et al. (2011): Mesencephalic Corticospinal Atrophy Predicts Baseline Deficit but Not Response to Unilateral or Bilateral Arm Training in Chronic Stroke. In: NEUROREHABILITATION AND NEURAL REPAIR 25 (1), S. 81–87. DOI: 10.1177/1545968310382001
Gonzenbach, Roman R.; Taegtmeyer, Anne B.; Luft, Andreas; Russmann, Stefan (2011): Fluoxetine and motor recovery after ischaemic stroke. In: LANCET NEUROLOGY 10 (6), S. 499–500
Hilty, Lea; Jaencke, Lutz; Luechinger, Roger; Boutellier, Urs; Lutz, Kai (2011): Limitation of Physical Performance in a Muscle Fatiguing Handgrip Exercise Is Mediated by Thalamo-Insular Activity. In: HUMAN BRAIN MAPPING 32 (12), S. 2151–2160. DOI: 10.1002/hbm.21177
Hilty, Lea; Langer, Nicolas; Pascual-Marqui, Roberto; Boutellier, Urs; Lutz, Kai (2011): Fatigue-induced increase in intracortical communication between mid/anterior insular and motor cortex during cycling exercise. In: EUROPEAN JOURNAL OF NEUROSCIENCE 34 (12), S. 2035–2042. DOI: 10.1111/j.1460-9568.2011.07909.x
Hosp, Jonas A.; Hertler, Benjamin; Atiemo, Clement Osei; Luft, Andreas R. (2011): Dopaminergic modulation of receptive fields in rat sensorimotor cortex. In: NEUROIMAGE 54 (1), S. 154–160. DOI: 10.1016/j.neuroimage.2010.07.029.
NEURAL PLASTICITY: Cortical Plasticity during Motor Learning and Recovery after Ischemic Stroke.
Hosp, Jonas A.; Luft, Andreas R. (2011): Cortical Plasticity during Motor Learning and Recovery after Ischemic Stroke. In: NEURAL PLASTICITY. DOI: 10.1155/2011/871296.
JOURNAL OF NEUROSCIENCE: Dopaminergic Projections from Midbrain to Primary Motor Cortex Mediate Motor Skill Learning
Hosp, Jonas A.; Pekanovic, Ana; Rioult-Pedotti, Mengia S.; Luft, Andreas R. (2011): Dopaminergic Projections from Midbrain to Primary Motor Cortex Mediate Motor Skill Learning. In: JOURNAL OF NEUROSCIENCE 31 (7), S. 2481–2487. DOI: 10.1523/JNEUROSCI.5411-10.2011.
Luft AR. The scientific basis of stroke rehabilitation.SWISS ARCHIVES OF NEUROLOGY AND PSYCHIATRY162 (2011): S. 167-168
Case reports in neurological medicine: An unusual cause of pseudomedian nerve palsy
Manjaly, Zina-Mary; Luft, Andreas R.; Sarikaya, Hakan (2011): An unusual cause of pseudomedian nerve palsy. In: Case reports in neurological medicine 2011, S. 474271. DOI: 10.1155/2011/474271.
Whitall, Jill; Waller, Sandy McCombe; Sorkin, John D.; Forrester, Larry W.; Macko, Richard F.; Hanley, Daniel F. et al. (2011): Bilateral and Unilateral Arm Training Improve Motor Function Through Differing Neuroplastic Mechanisms: A Single-Blinded Randomized Controlled Trial. In: NEUROREHABILITATION AND NEURAL REPAIR 25 (2), S. 118–129. DOI: 10.1177/1545968310380685.
Divani, Afshin A.; Vazquez, Gabriela; Brandy, Kyle R.; Barrett, Anna M.; Luft, Andreas R. (2010): Motor Function Impairment among Elderly Population with History of Stroke. In: NEUROLOGY 74 (9), S. A39-A39.
Lam, Judith M.; Globas, Christoph; Cerny, Joachim; Hertler, Benjamin; Uludag, Kamil; Forrester, Larry W. et al. (2010): Predictors of Response to Treadmill Exercise in Stroke Survivors. In: NEUROREHABILITATION AND NEURAL REPAIR 24 (6), S. 567–574. DOI: 10.1177/1545968310364059.
Lutz, Kai; Martin, Mike; Jaencke, Lutz (2010): Transfer of Motor Learning in a Visuomotor Tracking Task for Healthy Old and Young Adults. In: ZEITSCHRIFT FUR NEUROPSYCHOLOGIE 21 (4), S. 247–258. DOI: 10.1024/1016-264X/a000022.
Nadig, Karin Graziella; Jaencke, Lutz; Luechinger, Roger; Lutz, Kai (2010): Motor and non-motor error and the influence of error magnitude on brain activity. In: EXPERIMENTAL BRAIN RESEARCH 202 (1), S. 45–54. DOI: 10.1007/s00221-009-2108-7.
Waechter, Tobias; Roehrich, Sebastian; Frank, Anita; Molina-Luna, Katiuska; Pekanovic, Ana; Hertler, Benjamin et al. (2010): Motor skill learning depends on protein synthesis in the dorsal striatum after training. In: EXPERIMENTAL BRAIN RESEARCH 200 (3-4), S. 319–323. DOI: 10.1007/s00221-009-2027-7.
STROKE: Risk Factors Associated With Injury Attributable to Falling Among Elderly Population With History of Stroke.
Divani, Afshin A.; Vazquez, Gabriela; Barrett, Anna M.; Asadollahi, Marjan; Luft, Andreas R. (2009): Risk Factors Associated With Injury Attributable to Falling Among Elderly Population With History of Stroke. In: STROKE 40 (10), S. 3286–3292. DOI: 10.1161/STROKEAHA.109.559195
Ettlin, D. A.; Bruegger, M.; Keller, T.; Luechinger, R.; Jaencke, L.; Palla, S. et al. (2009): Interindividual differences in the perception of dental stimulation and related brain activity. In: EUROPEAN JOURNAL OF ORAL SCIENCES 117 (1), S. 27–33. DOI: 10.1111/j.1600-0722.2008.00590.x.
Hosp, J. A.; Molina-Luna, K.; Hertler, B.; Atiemo, C. Osei; Luft, A. R. (2009): DOPAMINERGIC MODULATION OF MOTOR MAPS IN RAT MOTOR CORTEX: AN IN VIVO STUDY. In: NEUROSCIENCE 159 (2), S. 692–700. DOI: 10.1016/j.neuroscience.2008.12.056.
Luft, Andreas R.; Schwarz, Stefanie (2009): Dopaminergic signals in primary motor cortex. In: INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE 27 (5), S. 415–421. DOI: 10.1016/j.ijdevneu.2009.05.004.
PLOS ONE: Dopamine in Motor Cortex Is Necessary for Skill Learning and Synaptic Plasticity.
Molina-Luna, Katiuska; Pekanovic, Ana; Roehrich, Sebastian; Hertler, Benjamin; Schubring-Giese, Maximilian; Rioult-Pedotti, Mengia-Seraina; Luft, Andreas R. (2009): Dopamine in Motor Cortex Is Necessary for Skill Learning and Synaptic Plasticity. In: PLOS ONE 4 (9). DOI: 10.1371/journal.pone.0007082.
Forrester, Larry W.; Wheaton, Lewis A.; Luft, Andreas R. (2008): Exercise-mediated locomotor recovery and lower-limb neuroplasticity after stroke. In: JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT 45 (2), S. 205–220. DOI: 10.1682/JRRD.2007.02.0034.
Funk, Marion; Lutz, Kai; Hotz-Boendermaker, Sabina; Roos, Malgorzata; Summers, Paul; Brugger, Peter et al. (2008): Sensorimotor tongue representation in individuals with unilateral upper limb amelia. In: NEUROIMAGE 43 (1), S. 121–127. DOI: 10.1016/j.neuroimage.2008.06.011.
Hosp, Jonas A.; Molina-Luna, Katiuska; Hertler, Benjamin; Atiemo, Clement Osei; Stett, Alfred; Luft, Andreas R. (2008): Thin-film epidural microelectrode arrays for somatosensory and motor cortex mapping in rat. In: JOURNAL OF NEUROSCIENCE METHODS 172 (2), S. 255–262. DOI: 10.1016/j.jneumeth.2008.05.010.
Luft, Andreas; Macko, Richard; Forrester, Larry; Goldberg, Andrew; Hanley, Daniel F. (2008): Post-stroke exercise rehabilitation: what we know about retraining the motor system and how it may apply to retraining the heart. In: Cleveland Clinic journal of medicine 75 Suppl 2, S. S83-6.
STROKE: Treadmill Exercise Activates Subcortical Neural Networks and Improves Walking After Stroke A Randomized Controlled Trial
Luft, Andreas R.; Macko, Richard F.; Forrester, Larry W.; Villagra, Federico; Ivey, Fred; Sorkin, John D. et al. (2008): Treadmill Exercise Activates Subcortical Neural Networks and Improves Walking After Stroke A Randomized Controlled Trial. In: STROKE 39 (12), S. 3341–3350. DOI: 10.1161/STROKEAHA.108.527531.
Megias-Alguacil, David; Keller, Thierry; Lutz, Kai; Barlow, Ashley P.; Ettlin, Dominik A. (2008): Design and construction of a magnetic resonance compatible multi-injector gas jet delivery system. In: REVIEW OF SCIENTIFIC INSTRUMENTS 79 (1). DOI: 10.1063/1.2823329.
Molina-Luna, Katiuska; Hertler, Benjamin; Buitrago, Manuel M.; Luft, Andreas R. (2008): Motor learning transiently changes cortical somatotopy. In: NEUROIMAGE 40 (4), S. 1748–1754. DOI: 10.1016/j.neuroimage.2007.11.018.
Roth, Patrick; Happold, Caroline; Eisele, Gfinter; Naegele, Thomas; Weller, Michael; Luft, Andreas R. (2008): A series of patients with subpial hemorrhage: Clinical manifestation, neuroradiological presentation and therapeutic implications. In: JOURNAL OF NEUROLOGY 255 (7), S. 1018–1022. DOI: 10.1007/s00415-008-0824-8.
Baumann, Simon; Koeneke, Susan; Schmidt, Conny F.; Meyer, Martin; Lutz, Kai; Jancke, Lutz (2007): A network for audio-motor coordination in skilled pianists and non-musicians. In: BRAIN RESEARCH 1161, S. 65–78. DOI: 10.1016/j.brainres.2007.05.045.
Blum, Julia; Lutz, Kai; Jaencke, Lutz (2007): Coherence and phase locking of intracerebral activation during visuo- and audio-motor learning of continuous tracking movements. In: EXPERIMENTAL BRAIN RESEARCH 182 (1), S. 59–69. DOI: 10.1007/s00221-007-0963-7.
Jaencke, Lutz; Lutz, Kai; Koeneke, Susan (2006): Converging evidence of ERD/ERS and BOLD responses in motor control research. In: EVENT-RELATED DYNAMICS OF BRAIN OSCILLATIONS 159, S. 261–271. DOI: 10.1016/S0079-6123(06)59018-1.
Koeneke, Susan; Lutz, Kai; Esslen, Michaela; Jaencke, Lutz (2006): How finger tapping practice enhances efficiency of motor control. In: NEUROREPORT 17 (15), S. 1565–1569.
Koeneke, S.; Lutz, K.; Herwig, U.; Ziemann, U.; Jaencke, L. (2006): Extensive training of elementary finger tapping movements changes the pattern of motor cortex excitability. In: EXPERIMENTAL BRAIN RESEARCH 174 (2), S. 199–209. DOI: 10.1007/s00221-006-0440-8.
Manto, M.; Ben Taib, N. O.; Luft, A. R. (2006): Modulation of excitability as an early change leading to structural adaptation in the motor cortex. In: JOURNAL OF NEUROSCIENCE RESEARCH 83 (2), S. 177–180. DOI: 10.1002/jnr.20733.
Luft, A. R.; Buitrago, M. M. (2005): Stages of motor skill learning. In: MOLECULAR NEUROBIOLOGY 32 (3), S. 205–216.
Luft, A. R.; Forrester, L.; Macko, R. F.; McCombe-Waller, S.; Whitall, J.; Villagra, F.; Hanley, D. F. (2005): Brain activation of lower extremity movement in chronically impaired stroke survivors. In: NEUROIMAGE 26 (1), S. 184–194. DOI: 10.1016/j.neuroimage.2005.01.027.
Buitrago, M. M.; Ringer, T.; Schulz, J. B.; Dichgans, J.; Luft, A. R. (2004): Characterization of motor skill and instrumental learning time scales in a skilled reaching task in rat. In: BEHAVIOURAL BRAIN RESEARCH 155 (2), S. 249–256. DOI: 10.1016/j.bbr.2004.04.025.
Buitrago, M. M.; Schulz, J. B.; Dichgans, J.; Luft, A. R. (2004): Short and long-term motor skill learning in an accelerated rotarod training paradigm. In: NEUROBIOLOGY OF LEARNING AND MEMORY 81 (3), S. 211–216. DOI: 10.1016/j.nlm.2004.01.001.
Ettlin, D. A.; Zhang, H.; Lutz, K.; Jarmann, T.; Meier, D.; Gallo, L. M. et al. (2004): Cortical activation resulting from painless vibrotactile dental stimulation measured by functional magnetic resonance imaging (fMRI). In: JOURNAL OF DENTAL RESEARCH 83 (10), S. 757–761.
Koeneke, S.; Lutz, K.; Wustenberg, T.; Jancke, L. (2004): Bimanual versus unimanual coordination: what makes the difference? In: NEUROIMAGE 22 (3), S. 1336–1350. DOI: 10.1016/j.neuroimage.2004.03.012.
JOURNAL OF NEUROSCIENCE Motor skill learning depends on protein synthesis in motor cortex after training.
Luft, A. R.; Buitrago, M. M.; Ringer, T.; Dichgans, J.; Schulz, J. B. (2004): Motor skill learning depends on protein synthesis in motor cortex after training. In: JOURNAL OF NEUROSCIENCE 24 (29), S. 6515–6520. DOI: 10.1523/JNEUROSCI.1034-04.2004.
Luft, A. R.; McCombe-Waller, S.; Whitall, J.; Forrester, L. W.; Macko, R.; Sorkin, J. D. et al. (2004): Repetitive bilateral arm training and motor cortex activation in chronic stroke - A randomized controlled trial. In: JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 292 (15), S. 1853–1861.
Luft, A. R.; Waller, S.; Forrester, L.; Smith, G. V.; Whitall, J.; Macko, R. F. et al. (2004): Lesion location alters brain activation in chronically impaired stroke survivors. In: NEUROIMAGE 21 (3), S. 924–935. DOI: 10.1016/j.neuroimage.2003.10.026.
Luft, A. R.; Waller, S.; Whitall, J.; Forrester, L.; Smith, G. V.; Macko, R.; Hanley, D. F. (2004): Bilateral training induces functionally relevant recruitment of contralesional motor cortex in chronic stroke survivors. In: STROKE 35 (6), S. E184-E184.
Partners & cooperations
Together with ETH Zürich (D- HEST, Prof. Gassert , Prof. Riener ), cereneo develops sensor technologies to be able to monitor stroke patients during their daily life. Metrics are also developed for measuring therapy effects and being able to inform doctors and patients about the progress of their recovery.
Together with Hocoma, cereneo develops new training devices and robots for arms and legs and tests their use in clinical studies.
Johns Hopkins University
Together with Johns Hopkins University, cereneo performs randomised, clinical studies in the area of arm rehabilitation using new robot training approaches.
Together with Twente University (Biomedical Signals and Systems, Prof. Dr. ir . Peter Veltink ), cereneo develops sensor and feedback technology for stroke patients.
"World-class medicine and corresponding treatment require exceptional performance from the team and the best research. And precisely this is found at cereneo. A global network of experts and the specialisation in neurotherapy enable us to achieve the best possible progress for our patients. We also assume that our approach will reduce therapy costs in the long term, as treatments are targeted and more intense."
Michael Horacek, CEO & President of the Administrative Council
Documents for referring physicians
Do you want to get to know our clinic personally?
Are you professionals and want to personally find out more about cereneo? Please contact us either by phone or in writing, stating your contact details and your professional background.